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Papers and Conference Presentations Produced by the Project

2013

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Whole-Genome Sequencing of Trypanosoma brucei Reveals Introgression between Subspecies That Is Associated with Virulence Ian Goodhead, Paul Capewell, J. Wendi Bailey, Tanja Beament, Michael Chance, Suzanne Kay, Sarah Forrester, Annette MacLeod, Mark Taylor, Harry Noyes, Neil Hall. mBio (2013) 4(4)e00197-13. doi:10.1128/mBio.00197-13

2012

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Novel SNP Discovery in African Buffalo, Syncerus caffer, Using High-Throughput Sequencing le Roex N, Noyes H, Brass A, Bradley DG, Kemp SJ, et al. (2012) PLoS ONE 7(11): e48792. doi:10.1371/journal.pone.0048792

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Trypanotolerance in N'Dama x Boran crosses under natural trypanosome challenge: effect of test-year environment, gender, and breed composition. Orenge C., Munga L., Kimwele C., Kemp S., Korol A., Gibson J., Hanotte O., Soller M. (BMC Genetics 2012; 13:87)

2011

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Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypanosoma congolense infection Harry Noyes, Andy Brass, Isaiah Obara, Susan Anderson, Alan L. Archibald, Dan G. Bradley, Paul Fisher, Abigail Freeman, John Gibson, Michael Gicheru, Laurence Hall, Olivier Hanotte, Helen Hulme, Declan McKeever, Caitriona Murray, Sung Jung Oh, Catriona Tate, Ken Smith, Miika Tapio, John Wambugu, Diana J. Williams, Morris Agaba, and Stephen J. Kemp Proceedings of the National Academy of Sciences

2010

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A Comprehensive Genetic Analysis of Candidate Genes Regulating Response to Trypanosoma congolense Infection in Mice Ian Goodhead, Alan Archibald, Peris Amwayi, Andy Brass, John Gibson, Neil Hall, Margaret A. Hughes, Moses Limo, Fuad Iraqi, Stephen J. Kemp, Harry A. Noyes PLoS Neglected Tropical Diseases 2010 4(11): e880. doi:10.1371/journal.pntd.0000880

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Claudin 13, a Member of the Claudin Family Regulated in Mouse Stress Induced Erythropoiesis Thompson PD, Tipney H, Brass A, Noyes H, Kemp S, Naessens J, Tassabehji M. PLoS ONE 2010; 5(9): e12667.

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High resolution mapping of trypanosomosis resistance loci Tir2 and Tir3 using F12 advanced intercross lines with major locus Tir1 fixed for the susceptible allele Nganga JK, Soller M, Iraqi F BMC Genomics 2010, 11:394

2009

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A Systematic Strategy for the Discovery of Candidate Genes Responsible for Phenotypic Variation Paul Fisher, Harry Noyes, Stephen Kemp, Robert Stevens and Andrew Brass. Methods in Molecular Biology: Vol 573 Cardiovascular Genomics 2009: 329-345

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Clinical chemistry of mice congenic for QTL for response to Trypanosoma congolense infection. Rathkolb B, Noyes HA, Brass A, Dark P, Fuchs H, Gailus-Durner V, Gibson J, Hrabé de Angelis M, Ogugo M, Iraqi F, Kemp SJ, Naessens J, Pope ME, Wolf E, Agaba M. Infection and Immunity 2009 77:3948–3957

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Pathways regulating response to Trypanosoma congolense infection in cattle Noyes, HA, Brass A, Anderson, SI; Archibald, AL; Fisher, P; Gibson, J; Hall, L; Hanotte, O; Hulme, H; McKeever, D; Oh, SJ; Rennie, C; Smith, K.C.; Wambugu, J; Williams, D; Kemp, SJ; Agaba, M (Oral Presentation, Bovine Genome Meeting, Cold Spring Harbour, May 2009)

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Transcriptional profiling of cattle infected with Trypanosoma congolense highlights gene expression signatures underlying trypanotolerance and trypanosusceptibility. O'Gorman G., Park S., Hill E., Meade K., Coussens P., Agaba M., Naessens J., Kemp S., MacHugh D. (BMC Genomics. 2009; 10:207)

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Mechanisms controlling anaemia in Trypanosoma congolense infected mice. Noyes H., Alimohammadian M., Agaba M., Brass A., Fuchs H., Gailus-Durner V., Hulme H., Iraqi F., Kemp S., Rathkolb B., Wolf E., de Angelis M., Roshandel D., Naessens J. PLoS One. 2009 44:e5170

2008

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Simulation of haplotype length over multiple generations suggests a simple linear relationship between numbers of haplotypes, number of generations and mean haplotype length Noyes, HA; Kemp SJ (Poster presented at the International Mammalian Genome Conference, Prague Nov 2008)

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Clinical chemistry of mice congenic for QTL for survival time after Trypanosoma congolense infection does not reveal major differences in respons to the parasite between short and long survivors infection. Rathkolb, B., Noyes, H.A., Brass, A., Dark, P., Fuchs, H., Gailus-Durner, V., Gibson, J., Hrabé de Angelis, M., Ogugo, M., Iraqi, F. et al. (Poster presented at the International Mammalian Genome Conference, Prague Nov 2008)

pdf image and link Conference Proceeding 2008. (145kb). " A systematic, data-driven approach to the combined analysis of microarray and QTL data."Rennie,K Hulme H, Fisher P, Hall L, Agaba M, Noyes HA, Kemp SJ & Brass A. Animal Genomics for Animal Health: Developments in Biologicals Vol 132: 293-300. Karger. (Proceedings of the Symposium on Animal Genomics for Animal Health. OIE HQ, World Organisation for Animal Health, Paris).

pdf image and link Conference Proceeding 2008. (48kb). "Genomics approaches to trypanosomiasis resistance - some surprises." Kemp SJ, Hanotte O, Agaba M, Noyes HA, Gibson J, Archibald A, Rennie C, Hulme H & Brass A. Animal Genomics for Animal Health: Developments in Biologicals Vol 132: 89-9. Karger. (Proceedings of the Symposium on Animal Genomics for Animal Health. OIE HQ, World Organisation for Animal Health, Paris).

pdf image and link Paper 2008. (422kb). "Strong position-dependent effects of sequence mismatches on signal ratios measured using long oligonucleotide microarrays" Rennie C; Noyes HA; Kemp SJ; Hulme H; Brass A; Hoyle DC. BMC Genomics 2008. 9: 317-328.

powerpoint image and link Presentation (4,090kb). "Genome-wide expression consequences of a disease resistance QTL are strongly influenced by the genetic background." Noyes HA. Presentation given at Ark Genomics Conference, Edinburgh, 7-9 April 2008.

powerpoint image and link Poster (3,275kb). "Genomics Approaches To Trypanosomiasis Resistance." Agaba,M, Anderson S, Archibald A, Brass A, Gibson J, Hall L, Hanotte O, Hulme H, Kemp SJ, Mwakaya J, Noyes HA, Ogugo M & Rennie C. Poster presented at Ark Genomics Conference, Edinburgh, 7-9 April 2008.

powerpoint image and link Poster (462kb). "A systematic, data-driven approach to the combined analysis of microarray and QTL data." Rennie,K Hulme H, Fisher P, Hall L, Agaba M, Noyes HA, Kemp SJ & Brass A. Poster presented at Ark Genomics Conference, Edinburgh, 7-9 April 2008.

powerpoint image and link Poster (390kb). "A transgenic approach to QTL analysis in a trypanotolerant mouse model." Rennie,K Hulme H, Fisher P, Hall L, Agaba M, Noyes HA, Kemp SJ & Brass A. Poster presented at Ark Genomics Conference, Edinburgh, 7-9 April 2008.

powerpoint image and link Poster (603kb). "Identifying candidate genes for the regulation of the response to Trypanosoma congolense infection." Noyes HA, Agaba M, Ogugo M, Brass A, Anderson S, Archibald A, Hulme H & Kemp SJ. Poster presented at BSP Spring Meeting, Newcastle, 29 March - 3 April 2008.

powerpoint image and link Poster (1,347kb). "Mismatches between probe and target sequences have a strong position-dependent effect on signal ratios from aCGH using 60mer oligonucleotide microarrays." Rennie C, Noyes HA, Kemp SJ, Hulme H, Brass AL & Hoyle, DC. Poster prepared for Genomes to Systems Conference, Manchester 17-20 March 2008.

powerpoint image and link Poster (841kb). "A Systematic approach to the Large-Scale Analysis of Genotype-Phenotype correlations." Fisher P. Poster prepared for NBIC/BioRange Meeting in Luterun, Netherlands 3rd March 2008.

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powerpoint image and link Presentation (7638kb). "A Systematic approach to the Large-Scale Analysis of Genotype-Phenotype correlations." Fisher P . Presentation at Joint European Bioinformatics (EBI) and Open Middleware Infrastructure Institute (OMII) on 5th October 2007 and Northwest Institute of BioHealth Informatics (NIBHI) on 9th January 2008 and NBIC/BioRange Meeting in Luterun, Netherlands 3rd March 2008.

2007

pdf image and link POSTER ABSTRACT (173kb). "A systematic strategy for the discovery of candidate genes responsible for phenotypic variation." Fisher P, Hedeler C, Wolstencroft K, Hulme H, Noyes HA, Kemp SJ, Stevens R & Brass A. Proceedings of the ISMB Meeting Vienna, Austria, 21 July 2007, Volume 8, Supplement 8.

powerpoint image and link Poster (506kb): "Using mouse models to decipher endotoxic shock during Trypanosoma congolense infection in cattle." Wambua L, Agaba M, Valentini A, Kemp SJ & members of the Wellcome Trust consortium. Poster prepared for John Vercoe Conference, International Livestock Research Institute, Nairobi, Kenya, 8 - 9 November 2007.

pdf image and link Poster (687kb): "Africa's cattle diversity. Why it matters. Agaba M, Kemp SJ, Wambugu J, Ogugo M, Nwamweya N & members of the Wellcome Trust consortium. Poster prepared for John Vercoe Conference, International Livestock Research Institute, Nairobi, Kenya, 8 - 9 November 2007.

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powerpoint image and link Poster (292kb): "Congenic mice models for the discovery of trypanotolerant genes in cattle." Wambugu J, Ogugo M, Nwamweya N, Kemp SJ & Agaba M. Poster prepared for John Vercoe Conference, International Livestock Research Institute, Nairobi, Kenya, 8 - 9 November 2007.

powerpoint image and link Powerpoint Presentation (74230kb). "Genomics approaches to trypanosomiasis resistance - some surprises." Kemp SJ. Presentation at International Symposium on Animal Genomics for Animal Health. OIE HQ, World Organisation for Animal Health, Paris France, 23-25 October 2007 .

powerpoint image and link Poster (525kb): Rennie C, Hulme H, Fisher P, Hall L, Agaba M, Noyes, HA, Kemp SJ & Brass A. "A Systematic, Data-Driven Approach To The Combined Analysis Of Microarray And QTL Data." Poster presented at International Symposium on Animal Genomics for Animal Health. OIE HQ, World Organisation for Animal Health, Paris France, 23-25 October 2007 .

powerpoint image and link Poster (3145kb): Agaba M, Hulme H, Rennie C, Mwakaya J, Brass A, & Kemp SJ. "Genome responses of trypanosome infected cattle. " Poster presented at International Symposium on Animal Genomics for Animal Health. OIE HQ, World Organisation for Animal Health, Paris France, 23-25 October 2007 .

powerpoint image and link Poster (390kb): Anderson S, Noyes HA Agaba M, Kemp SJ & Archibald A. "A transgenic approach to QTL analysis in a trypanotolerant mouse model. " Poster presented at International Symposium on Animal Genomics for Animal Health. OIE HQ, World Organisation for Animal Health, Paris France, 23-25 October 2007 .

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powerpoint image and link Poster (714kb). Noyes HA, Agaba M, Ogugo M, Brass A, Anderson S, Archibald A, Fisher P, Hulme H, Rennie C & Kemp SJ. "Congenic mice reveal effect of SNP, genomic rearrangements and expression variation on genome wide gene expression." Poster presented at International Symposium on Animal Genomics for Animal Health. OIE HQ, World Organisation for Animal Health, Paris France, 23-25 October 2007 .

powerpoint image and link Poster (2,452kb). Orenge CO, Korol AB, Kemp SJ, Kimwele CN, Munga LK, Gibson JP, Hanotte O, Dereck D, Nagda S, Murilla G & Soller M. " Detection of Quantitative Trait Loci (QTL) controlling trypanotolerance in a backcross of (N’Dama x Kenyan Boran) x Kenyan Boran cattle population under a natural tsetse and trypanosomosis field conditions in Narok District (Kenya)." Presentation at the International Scientific Council for Trypanosomiasis Research and ControI (ISCTRC) conference, Luanda, Angola. 1– 5 October 2007.

powerpoint image and link Powerpoint Presentation (12,365kb). Noyes HA, Agaba M, Gibson J, Hanotte O, Musa H, Mwakya J, Mwanga D, Nganga J, Ogugu M, Wambugu J, Anderson S, Archibald A, Brass A, Broadhead A, Daly D, Thomas L, Fisher P, Hulme H, Zeef L, Wardlesworth L, Kemp SJ, Rennie C. & Withers J. "Congenic mice infected with Trypanosoma congolense."Poster presented at Mouse Genetics Conference at Wellcome Trust Conference Centre, Hinxton, UK 5-9 September 2007.

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poster image and linnk POSTER (7,164kb): Noyes HA & Kemp SJ. "Simulating recombination over multiple generations." Mouse Molecular Genetics Conference at Wellcome Conference Centre, Hinxton 5-9 September 2007.

poster image and linnk POSTER (2,802kb): Noyes HA, Rennie C, Hulme H, Kemp SJ, Hoyle DC & Brass A. "Position specific effect of SNP on signal ratio from long oligonucleotide CGH microarrays; most single probe aberrations represent genuine genomic variants." Mouse Molecular Genetics Conference at Wellcome Conference Centre, Hinxton 5-9 September 2007.

pdf image and link Fisher P, Hedeler C, Wolstencroft K, Hulme H, Noyes H, Kemp SJ, Stevens R & Brass A. "Systematic Strategy for Large-Scale Analysis of Genotype-Phenotype Correlations: Identification of candidate genes involved in African Trypanosomiasis." Nucleic Acids Research 35 5625-5633.

poster image and linnk POSTER (715kb): Noyes HA, Agaba M, Ogugo M, Brass A, Anderson S, Archibald A, Fisher P, Hulme,H, Rennie C & Kemp SJ. "Congenic mice reveal effect of SNP, genomic rearrangements and expression variation on genome wide gene expression." Genomics of Common Diseases Conference at Wellcome Conference Centre, Hinxton 7-10 July 2007.

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powerpoint image and link Powerpoint Presentation (21,914kb). Kemp SJ. "Using livestock diversity to understand genome biology ."

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Movie insert (very large - 109,438kb) for above presentation.

Presentation given at:

1. National Academy of Sciences, ‘ Biological Sciences for the 21st Century: Meeting the Challenges of Sustainable Development In an Era of Global Change’, Washington DC, USA, May 2007.

2. Departmental Seminar at Chungnam National University, S.Korea, May 2007.

3. Departmental Seminar at Changbuk University, S. Korea, May 2007.

4. Departmental Seminar at Chinese Academy of Agricultural Sciences, China National Agriculture Research Institute, Beijing, China, May 2007.

powerpoint image and link Powerpoint Presentation (8,136kb). Dark P, Buchan I, Warhurst G, New J, Gibson M, Baker P, Rudenski A, Kemp SJ & Brass A. "Early and sustained acute falls in total serum cholesterol are associated with critical illness mortality in the setting of tight glycaemic control." Presentation given at The World Congress on Trauma, Shock, Inflammation and Sepsis - Interdisciplinary Summit on Inflammation 2007, Munich, March 2007.

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powerpoint image and link Powerpoint Presentation (7,445kb). Kemp SJ. "Functional genomics to explore host response to trypanosome infection in particular and stress in general." Presentation given at Animal Health Research: Recent Developments & Future Directions Conference, Wellcome Trust Genome Campus, Hinxton, UK, Jan 2007.

powerpoint image and link Powerpoint Presentation (7,365kb). Kemp SJ. "Functional genomics to identify genes and networks influencing survival following Trypanosome challenge." Presentation given at Liverpool University Biocomplexity Workshop, Liverpool November 2006.

powerpoint image and link Powerpoint Presentation (7,772kb). Kemp SJ. "Functional genomics to identify genes and networks influencing survival following Trypanosome challenge." Presentation given at trypanotolerance research meeting: French National Institute for Animal Research (INRA), Paris. December 2006.

powerpoint image and link Powerpoint Presentation (16,121kb). Noyes HA. "Identifying Pathways that intersect with Trypanosoma congolense response QTL." Presentation given at Euroscicon meeting: Animal health in the post-genomics era. MI Centre, London November 2006.

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poster image and link POSTER (7314kb): Noyes HA, Agaba M, Gibson JP, Ogugo M, Iraqi F, Brass A, Anderson S, Zeef L, Hulme H & Kemp SJ. "Congenic mice for the identification of genes responding to infection with Trypanosoma congolense." 18th International Mouse Genome Conference, Charleston, S. Carolina, 13-15 November 2006.

powerpoint image and link Powerpoint Presentation (11,891kb). Noyes HA. "Discovering the genes controlling response to Trypanosoma congolense infection." Presentation given to scientists at Institute of Experimental Genetics, GSF - National Research Center for Environment and Health, Germany October 2006.

pdf image and link Pdf of presentation (2,625kb). Gibson JP " Application of molecular genetic technologies for genetic improvement of ruminants."Presentation given to Asian-Australasian Association of Animal Science, Butan, Korea, September 2006.

pdf image and link O'Gorman GM, Park SD, Hill EW, Meade KG, Mitchell LC, Agaba M, Gibson JP, Hanotte O, Naessens J, Kemp SJ & Machugh DE. "Cytokine mRNA profiling of proliferol blood mononuclear cells (PBMC) from trypanotolerance and trypanosusceptible cattle infected with Trypanosoma congolense." Physiological Genomics 28 (1): 53-61.

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pdf image and link Kierstein S, Noyes HA, Naessens J, Nakamura Y, Pritchard C, Gibson J, Kemp SJ & Brass A. (2006). "Gene expression profiling in a mouse model for African trypanosomiasis." Genes and Immunity 7 (8) 667-679 .

poster image and link POSTER (590kb): Hassan M, Kemp SJ, Agaba M, Noyes HA, Naessens J, Iraqi F, Gibson, J, Rennie C, Hulme H, Hinsley T & Brass A. " The role of cholesterol in the pathology of African animal trypanosomiasis." ISAG 2006. 30th International Conference on Animal Genetics. Porto Seguro, Brazil, August 2006.

poster image and link POSTER (590kb): Alimohammadian M, Anderson S, Brass A, Gibson JP, Hulme H, Iraqi FA, Kemp SJ, Agaba M, Naessens J & Noyes HA. "Identification of gene networks associated with anaemia caused by Trypanosoma congolense." 11th International Congress of Parasitology, Glasgow. August 2006.

poster image and link POSTER (3,186kb): Noyes HA, Arana FE, Rizzo N, Kemp SJ, Hutchinson IV, Pravica V, Daly D &Arana BA. " Genetic Control of Cutaneous Leishmaniasis". 11th International Congress of Parasitology, Glasgow. August 2006.

poster image and link POSTER (3,186kb): Brass A, Broadhead A, Gibson JP, Iraqi FA, Kemp SJ, Musa H, Naessens J & Noyes HA. " Identification of gene networks associated with lipid response to infection with Trypanosoma congolense." 11th International Congress of Parasitology, Glasgow. August 2006.

poster image and link POSTER (9967kb): Noyes HA. "Pathways regulating response to Trypanosoma congolense infection." Parasitology Department, New York University, USA. July 2006.

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poster image and link POSTER (3,044kb): Noyes HA. "Identification of gene networks associated with lipid response to infection with Trypanosoma congolense." Gordon Research Conference on Lipoprotein Metabolism, South Hadley, Mass. USA. July 2006.

pdf image and linkBehnke JM, Iraqi FA, Mugambi JM, Clifford S, Nagda S, Wakelin D, Kemp SJ, Leydon Baker R & Gibson JP (2006). "High Resolution Mapping of Chromosomal Regions Controlling Resistance to Gastrointestinal Nematode Infections in an Advanced Intercross Line of Mice." Mammalian Genome 17: 584-597.

pdf image and linkNaessens J. (2006). Bovine trypanotolerance: A natural ability to prevent severe anaemia and haemophagocytic syndrome?" International Journal For Parasitology 36: 5: 521-528.

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poster image and linnk POSTER (652kb): Alimohammadian M, Anderson S, Brass A, Gibson JP, Hulme H, Iraqi FA, Kemp SJ, Mburu D, Naessens,J & Noyes HA. "Identification of gene networks associated with anaemia caused by Trypanosoma congolense."Genomes to Systems Conference: Manchester. March 2006.

pdf image and linkFoote SJ, Iraqi F & Kemp SJ. (2005). "Controlling malaria and African trypanosomiasis: The role of the mouse." Briefings in Functional Genomics and Proteomics 4(3): 214-224.

pdf image and link Hancock D, Wilson M, Velarde G, Morrison N, Hayes A, Hulme H, Wood AJ, Nashar K, Kell DB & Brass A (2005). "maxdLoad2 and maxdBrowse: standards-compliant tools for microarray experimental annotation, data management and dissemination." BMC Bioinformatics 2005 Nov 3: 6: 264-290.

pdf image and linkBishop R, Shah T, Pelle R, Hoyle D, Pearson T, Haines L, Brass A, Hulme H, Graham SP, Taracha EL, Kanga S, Lu C, Hass B, Wortman J, White O, Gardner MJ, Nene V & de Villiers EP (2005). "Analysis of the transcriptome of the protozoan Theileria parva using MPSS reveals that the majority of genes are transcriptionally active in the schizont stage." Nucleic Acids Research 33 (17) 5503-5511.

pdf image and linkHill EW, O'Gorman GM, Agaba M, Gibson JP, Hanotte O, Kemp SJ, NaessensJ, Coussens PM & MacHugh DE (2005). "Understanding bovine trypanosomiasis and trypanotolerance: the promise of functional genomics." Veterinary Immunology and Immunopathology 105 (3-4) 247-258.

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pdf image and linkNaessens J, Kitani H, NakamuraY, Yagi Y, Sekikawa K & Iraqi F (2005). "TNF-alpha mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection." Clinical and Experimental Immunology 139 (3) 405-410.

pdf image and linkGibson, J & Bishop SC (2005). "Use of molecular markers to enhance resistance of livestock to disease: A global approach." OIE Scientific & Technical Review 24 (1).

pdf image and link POSTER (Abstract only): Mburu D, Naessens J, Noyes H, Kemp SJ, Gibson J & Iraqi F. " Development of pathology in a/j, c57bl/6 and balb/c mice following Trypanosoma congolense infection." 18th International Mouse Genome Conference: Seattle. October 2004.

Chenyambuga SW, Hanotte O, HirboJ, Watts PC, Kemp SJ, Kifaro GC, Gwakisa PS, Petersen PH & Rege JEO (2004). "Genetic characterization of indigenous goats of sub-Saharan Africa using microsatellite DNA markers. " Asian-Australasian Journal of Animal Sciences 17 445-52.

pdf imageHanotte O, Ronin Y, Agaba M, Nilsson P, Gelhaus A, Horstmann R, Sugimoto Y, Kemp SJ, Gibson J, Korol A, Soller M & Teale A (2003). "Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle." Proceedings of the National Academy of Sciences of the United States of America 100 (13) 7443-8.

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Relevant publications: Related papers produced by team members but outside the consortium

pdf image and link Nganga J, Imbuga, MF & Iraqi. (2007). "Comparative genome analysis of trypanotolerance QTL." African Journal of Biotechnology 6 (8): 967-970.

pdf image and link Kazahiro Y, Agaba M, Iraqi F & Naessens J. (2007). "Cytokine mRNA profiles in bovine macrophages stimulated with Trypanosoma congolense." Journal of Veterinary Medical Science 69:421-423

pdf image and linkKoudane OD, van Arendonk JAM & Iraqi F (2005). "Marker-assisted introgression of trypanotolerance QTL in mice." Mammalian Genome 16 (2) 112-119.

pdf image and linkNaessens J, Kitani H, Momotani E, Sekikawa K, Ntahle JM & Iraqi F (2004). "Susceptibility of TNF-alpha-deficient mice to Trypanosoma congolense is not due to a defective antibody response." Acta Tropica 92 (3) 193-203.

pdf image and linkKitani H, Yagi Y, Naessens J, Sekikawa K & Iraqi F (2004). "The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-alpha gene." Acta Tropica 92 (1) 35-42.

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pdf image and linkNaessens J, Leak SGA, Kennedy DJ, Kemp SJ, & Teale AJ (2003). "Responses of bovine chimaeras combining trypanosomosis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense." Veterinary Parasitology 111(2-3) 125-142.

pdf image and linkNakamura Y, Naessens J, Takata M, Taniguchi T, Sekikawa K, Gibson J & Iraqi F (2003). "Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to Trypanosoma congolense infection." Parasitology Research 90 (2) 171-174.

pdf image and linkVan de Waaij EH, Hanotte O, van Arendonk JAM, Kemp SJ, Kennedy D, Gibson JP & Teale AJ (2003). "Population parameters for traits defining trypanotolerance in an F2 cross of N'Dama and Boran cattle." Livestock Production Science 84 219-230.

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pdf image and linkKitani H, Black SJ, Nakamura Y, Naessens J, Murphy NB, Yokomizo Y, Gibson J & Iraqi F (2002). "Recombinant tumor necrosis factor alpha does not inhibit the growth of African trypanosomes in axenic cultures." Infection and Immunity 70 (4) 2210-2214.

pdf image and linkClapcott SJ, Teale AJ, & Kemp SJ. (2000). "Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice." Parasite Immunology 22 (5) 259-263.

pdf image and linkIraqi F, Clapcott SJ, Kumari P, Haley CS, Kemp SJ, & Teale AJ (2000). "Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines." Mammalian Genome 11 (8) 645-648.

PDF OF PAPERHarrison RA, Moura Da-Silva AM, Laing GD, Wu Y, Richards A, Broadhead A, Bianco AE & Theakston RDG. (2000). Antibody from mice immunized with DNA encoding the carboxyl-disintegrin and cysteine-rich domain (JD9) of the haemorrhagic metalloprotease, Jararhagin, inhibits the main lethal component of viper venom. Clinical and Experimental Immunology 121 (2) 358-363.

PDF OF PAPERLagziel A, DeNise S, Hanotte O, Dhara S, Glazko V, Broadhead A, Davol R, Russo V & Soller M. (2000). Geographic and breed distribution of an Msp IPCR-RFLP in the bovine growth hormone (bGH) gene. Animal Genetics 31 (3) 210-213.

Teale A, Agaba M, Clapcott ST, Gelhaus A, Haley CH, Hanotte O, Horstmann R, Iraqi F, Kemp SJ, Nilsson P, Schwerin M, Sekikawa K, Soller M, Sugimoto Y & Womack J. "Resistance to trypanosomosis: of markers, genes and mechanisms." Proceedings of the International Symposium Candidate Genes for Animal Health, Rostock/Germany, 25-27 August 1999. Arch.Tierz.Dummerstorf 42, Special Issue, 36- 41.

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Nilsson P, Kang'a S, Rottengatter K, Suebeck U, Iraqi F, Mwakaya J, Mwangi D, Womack JE, Goldammer T, Schwerin M, Bradley D, Agaba M, Sugimoto K, Gelhaus A, Horstmann R, Teale A, Kemp S & Hanotte O. "Radiation hybrid maps of candidate trypanotolerance regions in cattle." Proceeding of the International Symposium Candidate Genes for Animal Health, Rostock/Germany, 25-27 August 1999. Arch.Tierz.Dummerstorf 42, Special Issue, 123-125 (hardcopy available from Kate Goodheart).

pdf image and linkKemp SJ & Teale AJ. (1998). "The genetic basis of trypanotolerance in mice and cattle." Parasitology Today 14 450-454.

pdf paperNoyes HA & Rambaut A (1998). Reply [to responses to Can Trypanosoma trees be trusted?]. Parasitology Today 14 335.

pdf paperNoyes HA (1998). Can trypanosoma trees be trusted? Parasitology Today 14 49-50.

pdf image and linkKemp SJ, Iraqi F, Darvasi A, Soller M & Teale AJ. (1997) "Localisation of genes controlling resistance to trypanosomiasis in mice." Nature Genetics 16 194-197.

pdf image and linkUimari P, Kemp SJ, Dekkers JCM, Teale AJ & Kennedy BW (1997). "Sensitivity of segregation analysis to data structure and transformation: a case study of trypanotolerance in mice." Heredity 78 424-432.

pdf image and linkKemp SJ, Darvasi A, Soller M & Teale AJ (1996). G"enetic control of resistance to trypanosomiasis." Veterinary Immunology and Immunopathology 54 239-243.

Kennedy DJ, Leak SGA, Kemp SJ, Teale AJ (1994). "Development of an n'dama x boran population segregating trypanotolerance." Theriogenology 41 226.

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